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DataBase of Tunicate Gene Regulation
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Gene product: tropomyosin-like
Organism: C. intestinalis
Summary of experimentsAbout 1.4 kb are enough for expression in notochord (Di Gregorio 1999)

A 114 bp long minimal enhancer was identified between -1392 and -1278. It contains two sets of low-affinity Brachyury half-sites: Ci-Bra-proximal 1/2 and Ci-Bra-distal 1/2.

Removal of Ci-Bra-distal 1/2 results in the loss of notochord expression (Di Gregorio 1999)
Activity reported

Ci-Bra regulates Ci-trop in notochord in C. intestinalis (6, 7, 28)
Sequences available
ID Gene Description Organism Dataset Dataset ID
s00391 Ci-trop -3000:+200 region of ci0100148830 C. intestinalis JGI 1 ci0100148830
s00392 Ci-trop -3000:+200 region of ci0200290543 C. intestinalis JGI 2 ci0200290543
s00393 Ci-trop -3000:+200 region of ENSCING00000008739 C. intestinalis JGI 2 ENSCING00000008739
  1. Kusakabe T. (2005). "Decoding cis-regulatory systems in Ascidians." Zoolog Sci 22:129-146. (PUBMED)
  2. Hotta, K., Takahashi, H., Asakura, T., Saitoh, B., Takatori, N., Satou, Y., Satoh, N. (2000). "Characterization of Brachyury-downstream notochord genes in the Ciona intestinalis embryo." Dev Biol 224:69-80. (PUBMED)
  3. Di Gregorio, A., Levin, M. (1999). "Regulation of Ci-tropomyosin-like, a Brachyury target gene in the acidian, Ciona intestinalis." Development 126:5599-5609. (PUBMED)