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DataBase of Tunicate Gene Regulation
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Gene product: T-box transcription factor Tbx6
Organism: C. intestinalis
Summary of experimentsCi-macho1 binds to 5'-GCCCCCCGCTG-3', the terminal Gs and the central CCC being critical for binding in vitro (Yagi 2004)
Despite the presence of possible Ci-macho1 binding sites the regulatory effects reported by Yagi et al. could be indirect.

Ci-ZicL is involved in expression of Ci-Tbx6b at the 64- and 110-cell stage
Activity reported

Ci-macho1 regulates Ci-Tbx6b in muscle in C. intestinalis (15)

Ci-ZicL regulates Ci-Tbx6b in muscle in C. intestinalis (2)
Sequences available
ID Gene Description Organism Dataset Dataset ID
s00366 Ci-Tbx6b -3000:+200 region of ci0100144249 C. intestinalis JGI 1 ci0100144249
s00367 Ci-Tbx6b -3000:+200 region of ci0200299257 C. intestinalis JGI 2 ci0200299257
s00368 Ci-Tbx6b -3000:+200 region of ENSCING00000003112 C. intestinalis JGI 2 ENSCING00000003112
  1. Yagi, K., Takatori, N., Satou, Y., Satoh, N. (2005). "Ci-Tbx6b and Ci-Tbx6c are key mediators of the maternal effect gene Ci-macho1 in muscle cell differentiation in Ciona intestinalis embryos." Dev Biol 282:535-549. (PUBMED)
  2. Yagi, K., Satoh, N., Satou, Y. (2004). "Identification of downstream genes of the ascidian muscle determinant gene Ci-macho1." Dev Biol 274:478-489. (PUBMED)